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The Lord of the Rings is an epic high-fantasy novel by English author and scholar J. R. R. Tolkien.Set in Middle-earth, intended to be Earth at some time in the distant past, the story began as a sequel to Tolkien's 1937 children's book The Hobbit, but eventually developed into a much larger work.Written in stages between 1937 and 1949, …















JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50 s of 1.9 μM and 830 nM respectively. JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway.








