SS31 has the advantages of a small molecular weight, stable structure, fast absorption, weak toxicity, and long half-life ; therefore, it is the most recognized small-molecule peptide among many mitochondrial targeted antioxidants. During all the experiments, no adverse drug reactions were evident in the mice.
Focal necrosis was indicated in SS31-, C-TK-SS31–, and SC-NO-SS31–treated groups. Cell sloughing and adhesion can be observed. Necrosis was rare in the SC-TK-SS31–treated mice with brush borders presented in tubules. The bottom images correspond to magnified views of the boxed areas above. Scale bar, 50 μm. All data are …
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All 12 proteins are known to interact with cardiolipin (CL, red). The proteins are grouped ... in magenta space-filled balls, and cross-linked residue K230 in green spheres. (C) Structural representation of b-SS31 and ADT interaction in the BKA-locked m-state (PDB: 6gci). Cross-linked lysines K33 and K272 are shown in green spheres and …
Oxidative stress serves a key role in doxorubicin (DOX)‑induced cardiotoxicity. The peptide Szeto‑Schiller (SS)31 is an efficacious antioxidant with the capacity to reduce mitochondrial reactive oxygen species (ROS) levels and scavenge free radicals. Although SS31 is involved in the pathophysiological process of various …
We detected the protective effects of mitochondrial-targeted peptide SS31 on ARPE-19 cells under oxidative damage through cell viability and morphology observation, apoptosis, and the mitochondrial function detection. We speculated the possible new strategies for preventing and treating AMD from the mitochondrial-targeted antioxidant …